Breast Health/Prevention
"Adjuvant tamoxifen improved recurrence-free and overall survival for premenopausal patients with tumors showing >75% PR-positive nuclei. No effect could be shown in tumors with fewer PR-positive nuclei. The PR was a stronger predictor of treatment response than the ER. Based on these findings, we suggest the implementation of a fractioned rather than dichotomized immunohistochemical evaluation of hormone receptors in clinical practice, possibly with greater emphasis on the PR than the ER."
"Overall, the 5-year local recurrence rate after BCT was low, but varied by subtype as approximated using ER, PR, and HER-2 status. Local recurrence was particularly low for the luminal A subtype, but was less than 10% at 5 years for all subtypes. Although further follow-up is needed, these results may be useful in counseling patients about their anticipated outcome after BCT."
"When the 1–2 years tamoxifen ER-poor group was subcategorised according to PgR, those with PgR-poor status were seen to gain no benefit from tamoxifen but the PgR-positive and PgR-unknown groups had risk reductions for relapse with relative risks of 14% ± 12 and 15% ± 5, respectively, the latter was highly significant. The corresponding figures for 5 years tamoxifen were 8% ± 15 and 21% ± 15 respectively."
"Quantitative expression of ER and PgR and HER-2 status did not identify patients with differential relative benefit from anastrozole over tamoxifen: TTR was longer for anastrozole than for tamoxifen in all molecular subgroups. Low ER or PgR or high HER-2 expression are associated with a high risk of recurrence with either anastrozole or tamoxifen."